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Additional types of endocrine signaling exist on the cellular level. While these still work with hormones, the level of production is far smaller than axis signaling. Autocrine signaling takes place within the cell itself, when a hormone is released through a chemical messenger that binds with receptors, creating a change in the cell.

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pandora charms Fig 1Flowchart showing numbers of women recruited and outcomes. CVS=chorionic villus sampling; DSS=Down’s syndrome screening; NIPT=non invasive prenatal testing; T13=trisomy 13; T18=trisomy 18; T21=trisomy 21. Including 15 women with risk 1/150 for T13/T18 and risk 1/151 1/1000 for T21. pandora charms

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